Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
نویسندگان
چکیده
منابع مشابه
Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia.
CONTEXT The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CAS...
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Aplastic anemia (AA) is nowadays considered to be a clonal disorder arising from a defective hematopoietic stem cell developing after a generalized insult to bone marrow. Immunosuppressive treatment (IST) of AA causes suppression of the target dominant population of haematopoietic cells allowing the defective non targeted clones to expand. This may give rise to acute leukemia. Cytogenetic studi...
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We report a case of t(8;21) acute myeloid leukemia presenting as severe aplastic anemia. While initial bone marrow biopsy lacked any cytogenetic abnormalities in 20 analyzed metaphases, repeat bone marrow biopsy eight days later demonstrated this translocation. Initial cytogenetic analysis of 20 metaphases was therefore insufficient to make the diagnosis of hypocellular acute myeloid leukemia. ...
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ژورنال
عنوان ژورنال: Sao Paulo Medical Journal
سال: 2004
ISSN: 1516-3180
DOI: 10.1590/s1516-31802004000600009